Diagnóstico y manejo de la neoplasia linfoproliferativa ovárica en paciente pediátrica: Análisis de caso
DOI:
https://doi.org/10.62452/h9nk6c04Keywords:
Neoplasm, ovarian non-Hodgkin lymphoma, pediatrics, oncologic diagnosis, chemotherapyAbstract
Primary ovarian lymphoma is a rare neoplasm, accounting for only 1-1.5% of ovarian cancers. Among these, Burkitt lymphoma is an aggressive and rapidly growing variant, more common in childhood. Due to its rarity, diagnosis may be delayed, affecting prognosis. This study presents the case of a 5-year-old patient with bilateral Burkitt-type ovarian lymphoma, highlighting its clinical characteristics, diagnosis, and treatment. A systematic review of the literature in indexed databases (2015-2024) was conducted, including a bibliometric analysis and a detailed study of the patient's medical history. Imaging, histopathological, and immunohistochemical studies were used to confirm the diagnosis. Staging was performed according to FIGO criteria and the Ziegler and Magrath system. The patient presented with abdominal distension and a palpable ovarian mass. Exploratory laparotomy revealed bilateral tumors with hemorrhagic secretion and peritoneal carcinomatosis. Histopathological analysis showed the characteristic "starry sky" pattern of Burkitt lymphoma. Immunohistochemistry confirmed the overexpression of CD20, CD19, and Ki67 (>95%). The case was classified as stage 1-A (FIGO) and stage C (Ziegler and Magrath). The patient received chemotherapy and showed a favorable outcome. Burkitt-type primary ovarian lymphoma should be considered in pediatric patients with ovarian masses and nonspecific symptoms. Early detection, immunohistochemical diagnosis, and timely treatment are important to improving prognosis and survival in these cases.
Downloads
References
Alberdi, N., Lopez, P., De La Fuente, P. R., De Arriba, C., Elduayen, B., & Esparza, J. (2021). El Linfoma de Burkitt: una entidad cada vez más frecuente en pediatría. Seram, 1(1). https://piper.espacio-seram.com/index.php/seram/article/view/4396/2862
Alderuccio, J. P., Olszewski, A. J., Evens, A. M., Collins, G. P., Danilov, A. V., Bower, M., & Cwynarski, K. (2021). HIV-associated Burkitt lymphoma: outcomes from a US-UK collaborative analysis. Blood advances, 5(14), 2852-2862. https://ashpublications.org/bloodadvances/article/5/14/2852/476385/HIV-associated-Burkitt-lymphoma-outcomes-from-a-US
Coral, D. (2016). Guia para hacer una revision bibliografica. https://lpl.unbosque.edu.co/wp-content/uploads/09-Guia-Revisio%CC%81n-bibliografica.pdf
De Campos Vieira Abib, S., Chui, C. H., Cox, S., Abdelhafeez, A. H., Fernandez-Pineda, I., Elgendy, A., Karpelowsky, J., Lobos, P., Wijnen, M., Fuchs, J., Hayes, A., & Gerstle, J. T. (2022). International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines. Ecancermedicalscience, 16. https://doi.org/10.3332/ecancer.2022.1356
Evens, A. M., et al. (2021). Burkitt lymphoma in the modern era: real-world outcomes and prognostication across 30 US cancer centers. Blood, 137(3), 374–386. https://doi.org/10.1182/blood.2020006926
Fajardo Ponce, G., Salinas Salinas, V., García Alejandro, f., Acosta Bowen, D., & Solorzano Armijos, X. (2021). Invaginación intestinal por un linfoma de Burkitt perforado en un paciente pediátrico: informe de un caso. canarias pediátrica, 45(3), 265-268. https://dialnet.unirioja.es/servlet/articulo?codigo=8390581
Faure-Conter, C., & Hameury, F. (2022). Tumores de los órganos genitales en pediatría. EMC-Pediatría, 57(4), 1-11. https://www.sciencedirect.com/science/article/abs/pii/S1245178922470880
Giménez-Campos, M. I., Laguna-Olmos, M., Ruiz-Peña, A. C., Domínguez-Eguizábal, B., Álvarez-Suberviola, E., & Vilas-Saura, L. (2022). Linfoma no Hodgkin primario de vagina o cuello uterino. Un diagnóstico en ocasiones incierto: a propósito de un caso. Ginecología y obstetricia de México, 90(11), 916-923. https://www.scielo.org.mx/pdf/gom/v90n11/0300-9041-gom-90-11-916.pdf
Janssen, C. L., Littooij, A. S., Fiocco, M., Huige, J. C., de Krijger, R. R., Hulsker, C. C., ... & Mavinkurve-Groothuis, A. M. (2021). The diagnostic value of magnetic resonance imaging in differentiating benign and malignant pediatric ovarian tumors. Pediatric Radiology, 51, 427-434. https://link.springer.com/article/10.1007/s00247-020-04871-2
Latorre-Rodríguez, A. R., Rodríguez-Chavarría, M. A., Acosta-Forero, B. J., & Ricaurte-Guerrero, O. (2022). Linfoma no Hodgkin primario de ovario: reporte de caso y revisión de la bibliografía. Ginecología y obstetricia de México, 90(9), 794-802. . https://www.scielo.org.mx/pdf/gom/v90n9/0300-9041-gom-90-09-794.pdf
Lee, I., & de Faria Ramos, A. (2022). Linfoma De Burkitt Primário Ovariano-Um Relato De Caso. Arquivos Catarinenses de Medicina, 51(1), 144-154. https://revista.acm.org.br/arquivos/article/view/900
Pourghasemian, M., Danandeh Mehr, A., Alavizadeh, E., Behzadi, F., & Roosta, Y. (2021). Primary bilateral ovarian involvement in Burkitt's lymphoma with an adnexal Torsion‐like manifestation: A case report. Clinical Case Reports, 9(11). https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.5058
Rodríguez, G., Alcalde, M., & Favier, R. (2023). Linfoma de Burkitt ovárico leucemizado. (Ponencia). Hematología, 2023. La Habana, Cuba.
Roschewski, M., et al. (2020). Multicenter study of risk-adapted therapy with dose-adjusted EPOCH-R in adults with untreated Burkitt lymphoma. Journal of clinical oncology, 38(22), 2519-2529. https://ascopubs.org/doi/full/10.1200/JCO.20.00303
Sergi, W., Marchese, T. R. L., Botrugno, I., Baglivo, A., & Spampinato, M. (2021). Primary ovarian Burkitt's lymphoma presentation in a young woman: A case report. International Journal of Surgery Case Reports, 83. https://www.sciencedirect.com/science/article/pii/S2210261221004065
Tovio Martínez, I. P., Tovio Martínez, E. G., & Urbano del Valle, S. E. (2020). Hepatoesplenomegalia relacionada a linfoma de Burkitt en paciente pediátrico. Revista Médica Electrónica, 42(5), 2378-2387. http://scielo.sld.cu/pdf/rme/v42n5/1684-1824-rme-42-05-2378.pdf
Xiao, C., Chen, S. R., Wang, C. C., Shen, M. H., Cao, D., & Lyu, J. H. (2020). Clinicopathological analysis of bilateral ovarian Burkitt lymphoma. Zhonghua bing li xue za zhi= Chinese journal of pathology, 49(11), 1180-1182. https://pubmed.ncbi.nlm.nih.gov/33152827/
Xu, H., Zhao, C., Wang, Q., Chen, Y., Zhang, W., Zhuang, Y., Chen, R., & Zhang, H. (2022). Primary ovarian Burkitt lymphoma: report of a case and review of literature. International journal of clinical and experimental pathology, 15(3), 110–119. https://pubmed.ncbi.nlm.nih.gov/35414839/
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Guido Nino Guida-Acevedo, Rafael Martín Franco-Delgado, Leonardo Alejandro Bustamante-Coello, Roberto Javier Aguilar-Berrezueta (Autor/a)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The authors retain the copyright, granting the Journal the right to first publication of the work. The authors assign the Journal the rights to exploit the work, authorizing its distribution and public communication for non-commercial purposes. The authors retain the moral rights to the published work. The economic rights belong to the Journal.
