Bone metabolism alterations in patients with advanced renal failure: clinical and pathophysiological analysis.
DOI:
https://doi.org/10.62452/qaan8c76Keywords:
Chronic kidney disease, bone metabolism, renal osteodystrophy, secondary hyperparathyroidism, pathophysiologyAbstract
Bone disorders associated with advanced renal failure represent one of the most complex manifestations of chronic kidney disease–mineral and bone disorder (CKD-MBD), resulting from multifactorial imbalances affecting calcium, phosphate, parathyroid hormone, and vitamin D homeostasis. Chronic renal dysfunction progressively disrupts mineral metabolism, leading to renal osteodystrophy, pathological fractures, and vascular calcifications. These complications directly impact patients’ quality of life and prognosis, requiring an integrated approach based on biochemical, densitometric, and clinical assessment. Understanding the connection between physiological processes and bone tissue responses allows for the optimization of therapeutic strategies, focusing on controlling secondary hyperparathyroidism and correcting nutritional and hormonal deficiencies. Currently, interdisciplinary management and continuous monitoring of mineral metabolism are essential to mitigate skeletal complications and improve survival in advanced renal disease. This analysis underscores the importance of integrating pathophysiological knowledge with clinical practice to promote more effective and personalized patient care.
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Copyright (c) 2025 Alex Ramón Valencia-Herrera, María José Herrera-Manobanda, Katherin Mishell Chiluisa-Vaca, Xavier Timoteo Quezada-Erazo (Autor/a)
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