Systemic lupus erythematosus as a preexisting disease or secondary to an inflammatory syndrome in a patient with HIV. Case report
DOI:
https://doi.org/10.62452/87182817Keywords:
Systemic lupus erythematosus, HIV, concomitants, immune reconstitution, autoimmune diseaseAbstract
The coexistence of autoimmune diseases in patients with HIV is rare. Various signs, symptoms, and laboratory parameters, especially antibodies, can be observed between both pathologies, which may go unnoticed in an autoimmune disease or, conversely, lead to an erroneous diagnosis. A 32-year-old male patient with a history of acquired immunodeficiency virus (HIV) and hypogonadism before the HIV diagnosis presented with polyarthritis lasting more than two months. A possible immune reconstitution syndrome (IRIS) associated with an autoimmune disease (AD) or preexisting AD is suspected. This sign and symptom can be present in more than one AD, in this case, Systemic Lupus Erythematosus (SLE), and timely diagnosis is necessary to initiate treatment and prevent complications or mortality.
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References
Araúz, A. B., & Papineni, P. (2021). Histoplasmosis. Infectious disease clinics of North America, 35(2), 471–491. https://doi.org/10.1016/j.idc.2021.03.011
Carugati, M., Franzetti, M., Torre, A., Giorgi, R., Genderini, A., Strambio de Castilla, F., Gervasoni, C., & Riva, A. (2013). Systemic lupus erythematosus and HIV infection: a whimsical relationship. Reports of two cases and review of the literature. Clinical rheumatology, 32(9), 1399–1405. https://doi.org/10.1007/s10067-013-2271-x
Chamberlain, F. E., Dinani, N., Singh, G. K. J., Bower, M., & Nelson, M. (2014). Azathioprine can be safely used in HIV-infected individuals. AIDS, 28(3), 447–448. https://journals.lww.com/aidsonline/citation/2014/01280/azathioprine_can_be_safely_used_in_hiv_infected.19.aspx
Fox, C., & Walker, K. (2015). Evolving spectrum of HIV-associated rheumatic syndromes. Best Practice & Research: Clinical Rheumatology, 29(2), 244–255. https://doi.org/10.1016/j.berh.2015.04.019
Fox, R., & Isenberg, D. (1997). Human immunodeficiency virus infection in systemic lupus erythematosus. Arthritis & Rheumatism, 40(6), 1168–1172. https://onlinelibrary.wiley.com/doi/full/10.1002/art.1780400623
Gould, T., & Tikly, M. (2004). Systemic lupus erythematosus in a patient with human immunodeficiency virus infection: Challenges in diagnosis and management. Clinical Rheumatology, 23(2), 166–169. https://link.springer.com/article/10.1007/s10067-003-0833-z
Guitton, Z., Viget, N., Surgers, L., Cheret, A., Fontier, C., Deconinck, L., Bataille, P., Meybeck, A., Bazus, H., & Robineau, O. (2022). Impact and tolerance of immunosuppressive treatments in patients living with HIV with inflammatory or autoimmune diseases. Microorganisms, 10(10), 1891. https://doi.org/10.3390/microorganisms10101891
Hax, V., Didonet Moro, A. L., Piovesan, R. R., Goldani, L. Z., Xavier, R. M., & Monticielo, O. A. (2018). Human immunodeficiency virus in a cohort of systemic lupus erythematosus patients. Advances in Rheumatology, 58(1), 3. https://doi.org/10.1186/s42358-018-0003-2
Hernández, R., Fernández, C & Baptista, P. (2010). Metodología de la investigación. McGraw Hill.
Liao, H., Tao, C., & Su, J. (2017). Concomitant systemic lupus erythematosus and HIV infection: A rare case report and literature review. Medicine, 96(51). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758215/
O’Kelly B, McNally C, McConkey S, Durcan L. HIV and systemic lupus erythematosus: where immunodeficiency meets autoimmunity. Lupus. 2020;29(9):1130-1132. https://journals.sagepub.com/doi/10.1177/0961203320934851
Okada, A., Nozaki, Y., Rai, S., Kinoshita, K., Funauchi, M., & Matsumura, I. (2021). Antiretroviral Therapy Improves Acquired Immunodeficiency Syndrome with Systemic Lupus Erythematosus. Life, 11(6), 463. https://doi.org/10.3390/life11060463
Quaglia, M., Merlotti, G., De Andrea, M., Borgogna, C., & Cantaluppi, V. (2021). Viral Infections and Systemic Lupus Erythematosus: New Players in an Old Story. Viruses, 13(2), 277. https://doi.org/10.3390/v13020277
Raj, T. Y., Sujith, S., Srinivasaprasad, N. D., Valavan, K. T., Hema, M., Kurien, A. A., & Fernando, E. (2019). Lupus nephritis in a patient with retroviral infection. Saudi Journal of Kidney Diseases and Transplantation, 30(2), 520–525. https://doi.org/10.4103/1319-2442.256861
Reveille, J. (2000). The changing spectrum of rheumatic disease in human immunodeficiency virus infection. Seminars in Arthritis and Rheumatism, 30(3), 147–166. https://doi.org/10.1053/sarh.2000.16527
Sachdeva, R., & Pal, R. (2022). The influence of reproductive hormones on systemic lupus erythematosus. Exploration of Immunology, 2, 351–362. https://doi.org/10.37349/ei.2022.00055
Virot, E., Duclos, A., Adelaide, L., Miailhes, P., Hot, A., Ferry, T., & Seve, P. (2017). Autoimmune diseases and HIV infection: A cross-sectional study. Medicine, 96(4), e5769. https://doi.org/10.1097/MD.0000000000005769
Walker, U., Tyndall, A., & Daikeler, T. (2008). Rheumatic conditions in human immunodeficiency virus infection. Rheumatology, 47(7), 952–959. https://doi.org/10.1093/rheumatology/ken132
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