Integrated therapeutic interventions in benign and malignant oral soft tissue pathologies: Critical review of surgical and pharmacological approaches
DOI:
https://doi.org/10.62452/jbc1yt58Keywords:
Oral soft tissues, oral surgery, pharmacotherapy, oral neoplasms, integrated treatmentAbstract
Oral soft tissue lesions, whether benign or malignant, present diagnostic and therapeutic challenges in clinical dental practice. This literature review critically examines surgical and pharmacological interventions employed in the management of these conditions, assessing their efficacy, indications, and limitations. Scientific databases such as PubMed, Scopus, and SciELO were consulted, prioritizing recent studies with high methodological quality. Findings highlight the importance of a multidisciplinary approach that combines precise surgical excision with the rational use of pharmacological agents, including antibiotics, corticosteroids, and immunomodulators, depending on the lesion’s type and aggressiveness. Furthermore, the review emphasizes the need to tailor treatment plans based on each patient’s clinical and systemic characteristics to optimize functional and aesthetic outcomes. Regular clinical follow-up and early detection are essential strategies for preventing recurrences and improving prognosis.
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References
Al-Noaman, A. S. (2020). Pyogenic granuloma: Clinicopathological and treatment scenario. Journal of Indian Society of Periodontology, 24(3), 233–236. https://doi.org/10.4103/jisp.jisp_132_19
Aziz, Y., Rademacher, W. M. H., Hielema, A., Wishaw, S. B. P., van Diermen, D. E., de Lange, J., Vissink, A., & Rozema, F. R. (2021). Oral adverse effects: Drug-induced tongue disorders. Oral Diseases, 27(6), 1528–1541. https://doi.org/10.1111/odi.13680
Bernaola-Paredes, W. E., Rodrigues, M. L., Carvalho, H. P., dos Santos Bitencourt, F., Coutinho, M. C., D’Almeida Costa, F., Vallejo-Rosero, K. A., Marquez-Zambrano, J. A., & Pellizzon, A. C. A. (2023). Reconstructive surgery and adjuvant radiotherapy for the multimodal approach in oral cancer: A single cancer centre experience. Annals of Medicine and Surgery, 85(11), 5314–5322. https://doi.org/10.1097/MS9.0000000000001357
Chaturvedi, A. K., Udaltsova, N., Engels, E. A., Katzel, J. A., Yanik, E. L., Katki, H. A., Lingen, M. W., & Silverberg, M. J. (2020). Oral leukoplakia and risk of progression to oral cancer: A population-based cohort study. JNCI: Journal of the National Cancer Institute, 112(10), 1047–1054. https://doi.org/10.1093/jnci/djz238
Girotra, C., Padhye, M., Mahajan, P., Savla, S., Nair, A., Pardeshi, P., Tomar, G., & Kini, Y. (2023). Is paracetamol better than diclofenac sodium in management of postoperative pain and edema following major maxillofacial surgeries? Journal of Maxillofacial and Oral Surgery, 22(1), 187–195. https://doi.org/10.1007/s12663-022-01806-2
Lauritano, D., Lucchese, A., Gabrione, F., Di Stasio, D., Silvestre Rangil, J., & Carinci, F. (2019). The effectiveness of laser-assisted surgical excision of leukoplakias and hyperkeratosis of oral mucosa: A case series in a group of patients. International Journal of Environmental Research and Public Health, 16(2), 210. https://doi.org/10.3390/ijerph16020210
Li, H., Zhang, Y., Xu, M., & Yang, D. (2022). Current trends of targeted therapy for oral squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology, 148(9), 2169–2186. https://doi.org/10.1007/s00432-022-04028-8
Maddalo, M., Borghetti, P., Tomasini, D., Corvò, R., Bonomo, P., Petrucci, A., et al. (2020). Cetuximab and radiation therapy versus cisplatin and radiation therapy for locally advanced head and neck cancer: Long-term survival and toxicity outcomes of a randomized phase 2 trial. International Journal of Radiation Oncology, Biology, Physics, 107(3), 469–477. https://doi.org/10.1016/j.ijrobp.2020.02.637
Minic, I. (2020). Oral manifestations associated with human immunodeficiency virus. Journal of Dental Disorders, 6(3), 1135. https://austinpublishinggroup.com/dental-disorders/fulltext/jdod-v6-id1135.php
Parag-Sharma, K., Tasoulas, J., Musicant, A. M., do Nascimento-Filho, C. H. V., Zhu, Z., Twomey, C., Liu, P., Castilho, R. M., & Amelio, A. L. (2021). Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma. Oral Oncology, 115, 105166. https://doi.org/10.1016/j.oraloncology.2020.105166
Pirmoradi, Z., Nazari, K., Shafiee, N., Nikoukar, N., Minoo, S., Ghasemi, H., Ghanbarikondori, P., & Allahyartorkaman, M. (2024). Oral cancer and HPV: Review article. Asian Pacific Journal of Cancer Biology, 9(1), 87–95. https://doi.org/10.31557/apjcb.2024.9.1.87-95
Radulescu, M. (2023). Diagnosis and management of recurrent lesions of the oral mucosa. En H. Dym, L. R. Halpern, & O. E. Ogle (Eds.), Oral and maxillofacial surgery, medicine, and pathology for the clinician (pp. 131–141). Wiley.
Yarkaç, F., & Gokturk, O. (2019). Use of diode laser in the treatment of pyogenic granuloma on the mandible: A case series. Saudi Journal of Oral and Dental Research, 4(8), 518–523. https://saudijournals.com/media/articles/SJODR-48-518-523-c.pdf
Yoshida, S., Kawai, H., Soe, Y., Eain, H. S., Sanou, S., Takabatake, K., Takeshita, Y., Hisatomi, M., Nagatsuka, H., Asaumi, J., & Yanagi, Y. (2024). Efficacy of cisplatin-CXCR4 antagonist combination therapy in oral cancer. Cancers, 16(13), 2326. https://doi.org/10.3390/cancers16132326
Yusuf, C. T., Heron, M. J., Girard, A. O., Zhu, K. J., Lopez, C. D., & Yang, R. (2023). Ill-fitting dental appliances and oral cancer: A systematic review and case report. FACE, 4(3), 417–425. https://doi.org/10.1177/27325016231187572
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