Contemporary clinical approach to inflammatory sialadenopathy: Critical analysis of the scientific literature
DOI:
https://doi.org/10.62452/16gmq359Abstract
Inflammatory sialadenopathies encompass a heterogeneous group of disorders affecting the major and minor salivary glands, with etiologies ranging from acute bacterial infections to chronic autoimmune processes. This literature review aims to critically examine recent scientific publications on the diagnosis and treatment of these conditions, identifying the most updated and effective clinical approaches. Articles were selected from databases such as PubMed, Scopus, and SciELO, prioritizing clinical studies and systematic reviews published in the last ten years. Findings emphasize the need for comprehensive assessment involving advanced imaging, serological tests, and, in complex cases, glandular biopsy. The emerging role of targeted antibiotics and immunomodulatory therapies is also highlighted, along with the importance of multidisciplinary collaboration. Early diagnosis and appropriate intervention are essential to prevent complications and preserve salivary gland function.
Downloads
References
Bag, A. K., Curé, J. K., Chapman, P. R., Singhal, A., & Haneef Mohamed, A. W. (2018). Imaging of inflammatory disorders of salivary glands. Neuroimaging Clinics of North America, 28(2), 255–272. https://doi.org/10.1016/j.nic.2018.01.006
Blitzer, A. (1987). Inflammatory and obstructive disorders of salivary glands. Journal of Dental Research, 66(Spec No 1_suppl), 675–679. https://doi.org/10.1177/00220345870660S112
Caro, L. J., Fuentes, L. N., & Iñiguez, C. R. (2015). Evidencia y uso actual de toxina botulínica en patología otorrinolaringológica. Revista de Otorrinolaringología y Cirugía de Cabeza y Cuello, 75(1), 67–76. https://doi.org/10.4067/S0718-48162015000100011
Daniels, K. E., & Schaitkin, B. M. (2021). An update on nontumorous disorders of the salivary glands and their management for internists. Medical Clinics of North America, 105(5), 839–847. https://doi.org/10.1016/j.mcna.2021.05.006
González Sánchez, Y., Carreras Martorell, C. L., Jiménez Fuentes, A., Gutiérrez Galán, I., & Duany Baderas, K. (2020). Efectividad de la succión desembrozante en pacientes con procesos inflamatorios de las glándulas salivales mayores. MediSan, 24(1), 76–87. https://www.redalyc.org/journal/3684/368462717008/368462717008.pdf
González Sánchez, Y., Carreras Martorell, C. L., Jiménez Fuentes, A., Gutiérrez Galán, I., & Duany Baderas, K. (2020). Efectividad de la succión desembrozante en pacientes con procesos inflamatorios de las glándulas salivales mayores. MediSan, 24(1), 76–87. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192020000100076&lng=es
Hammett, J. T., & Walker, C. (2024). Sialolithiasis. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/sites/books/NBK549845/
Hidalgo, J., Delucchi, P., Sepúlveda, I., & Alarcón, R. (2023). Cirugía de desfuncionalización de glándulas salivales mayores en sialorrea masiva. Revista de Otorrinolaringología y Cirugía de Cabeza y Cuello, 83(2), 141–149. https://doi.org/10.4067/S0718-48162023000200141
Kallas-Silva, L., Dias Azevedo, M. F., Mendes de Matos, F. C., Picado Petrarrolha, S., Dedivitis, R. A., Kulcsar, M. A. V., & Luongo Matos, L. (2023). Sialendoscopy for treatment of major salivary glands diseases: A comprehensive analysis of published systematic reviews and meta-analyses. Brazilian Journal of Otorhinolaryngology, 89(5), 101293. https://doi.org/10.1016/j.bjorl.2023.101293
Klinovskaya, A. S., Gurgenadze, A. P., Bazikyan, E. A., Abrahamyan, K. D., & Chunikhin, A. A. (2020). Sialendoscopy in diagnosis and treatment of salivary gland disorders. Stomatologiia (Mosk), 99(3), 83–86. https://doi.org/10.17116/stomat20209903183
Liljekvist, M. S., Foghsgaard, J., & Howitz, M. F. (2023). Sialendoscopy for pediatric salivary gland disorders: A study of safety and effect. European Archives of Oto-Rhino-Laryngology, 280(4), 1927–1937. https://doi.org/10.1007/s00405-022-07747-3
Mailly, M., Sené, T., Majer, J., Katz, P., & Brasnu, D. (2021). Positive effects of local botulinum toxin injection and colchicine for complicated chronic recurrent parotitis: A case report. Journal of Oral and Maxillofacial Surgery, 79(2), 383–388. https://doi.org/10.1016/j.joms.2020.08.008
Nocturne, G., & Gosset, M. (2023). Pathologies inflammatoires des glandes salivaires [Inflammatory diseases of the salivary]. La Revue du Praticien, 73(7), 747–750. https://pubmed.ncbi.nlm.nih.gov/37796262/
Scherl, C. (2021). Seltene Erkrankungen der Speicheldrüsen und des Nervus Facialis. Laryngorhinootologie, 100(S 01), S1–S28. https://doi.org/10.1055/a-1337-6994
Strychowsky, J. E., Sommer, D. D., Gupta, M. K., Cohen, N., & Nahlieli, O. (2012). Sialendoscopy for the management of obstructive salivary gland disease: A systematic review and meta-analysis. Archives of Otolaryngology–Head & Neck Surgery, 138(6), 541–547. https://doi.org/10.1001/archoto.2012.856
Tupac Ramírez, A., Latorre-Quintana, M., & Carvajal, J. (2022). Sialoendoscopia y abordaje mixto para el manejo de la patología obstructiva de las glándulas salivales. Revista Colombiana de Cirugía, 37(4), 574-579. https://doi.org/10.30944/20117582.2136
Wilson, M., & Pandey, S. (2024). Parotitis. StatPearls Publishing. https://pubmed.ncbi.nlm.nih.gov/32809570/
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Mónica Sofía Pallo-Sarabia, Emilie Dominique Vásconez-Mayorga, Luis Miguel Acosta-Rueda (Autor/a)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors who publish in Revista Metropolitana de Ciencias Aplicadas (REMCA), agree to the following terms:
1. Copyright
Authors retain unrestricted copyright to their work. Authors grant the journal the right of first publication. To this end, they assign the journal non-exclusive exploitation rights (reproduction, distribution, public communication, and transformation). Authors may enter into additional agreements for the non-exclusive distribution of the version of the work published in the journal, provided that acknowledgment of its initial publication in this journal is given.
© The authors.
2. License
The articles are published in the journal under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0). The terms can be found at: https://creativecommons.org/licenses/by-nc-sa/4.0/deed.en
This license allows:
- Sharing: Copying and redistributing the material in any medium or format.
- Adapting: Remixing, transforming, and building upon the material.
Under the following terms:
- Attribution: You must give appropriate credit, provide a link to the license, and indicate if any changes were made. You may do this in any reasonable manner, but not in any way that suggests the licensor endorses or sponsors your use.
- NonCommercial: You may not use the material for commercial purposes.
- ShareAlike: If you remix, transform, or build upon the material, you must distribute your creation under the same license as the original work.
There are no additional restrictions. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.